Randomised Interventional study to evaluate the effectiveness of autologous PRP injection versus conventional Povidone Iodine dressing in the treatment of single acute post traumatic skin wound healing

Subjects admitted in Plastic surgery ward for the treatment of single acute post traumatic wound (otherwise healthy without co morbidities) are selected after wound debridement with consent from both the subjects and treating surgeon as per the inclusion and exclusion criteria. Study group(with PRP injection) /control group (povidone dressing) assigned as mentioned under randomization and allocation concealment method. Initial Ulcer area is recorded on day 0. Study subjects receive PRP Injection which is prepared by the PI and infiltrated in wound by the treating surgeon followed by non adhesive dressing done. Control subjects receive routine conventional povidone iodine dressing. Both these procedures done twice weekly. At the end of every week , size of wound area is noted as per treating surgeon advise. PUSH score of healing also recorded simultaneously. The initial wound area is considered as 100%. Thus the mean reduction in size of wound (area in %) at the end of every week is noted till discharge of both study and control subjects.

Mean duration of hospital stay is calculated for both study and control subjects.

Thus by comparing the rate of healing (% reduction in wound size) during the first/second  week by two different method of treatment helps to rejuvenate further upcoming treatment.

Platelet Rich Plasma (PRP) preparation: PRP is prepared only after treating surgeon consent by receiving 8.5 ml whole blood of study subject in Acid citrate vial. The procedure is done under specific standard operating procedure followed at Mahatma Gandhi hospital Blood Centre as per NABH standards.