Aspirin Use and Postoperative Bleeding From Dental Extractions in a Healthy Population

Phase 2

Completed

• Conditions: Bleeding Complication

• Registration Number: NCT00405613
• Lead Sponsor: Wake Forest University Health Sciences

Brief Summary

The purpose of this study is to determine if aspirin is associated with bleeding complications following a single tooth extraction

Detailed Description

Aspirin is a common chronically administered preventive treatment for cardiovascular disease, but is often discontinued prior to invasive dental procedures because of concern of bleeding complications. As the goal of aspirin is often to prevent MI and stroke, the risk of these CVD outcomes with discontinuation of aspirin must be weighed against the perceived adverse event of bleeding during or following an invasive dental procedure with continuation of aspirin. The current study is a randomized controlled trial evaluating bleeding complications of aspirin vs. placebo in healthy patients schedule for a single tooth extraction.

Study Timeline

• Study Start: 2003-05
• Study Completion: 2005-12
• Status Verified: 2006-11
• Study First Submitted: 2006-11-28
• Study First Submitted QC: 2006-11-28
• Study First Posted: 2006-11-30
• Last Update Submitted: 2022-04-19
• Last Update Posted: 2022-04-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 36

Inclusion Criteria

• Healthy
• Require a simple tooth extraction

Exclusion Criteria

• Use of previous aspirin or NSAID

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Oral bleeding time

Secondary Outcome Measures

Name	Time	Method
Report of bleeding at phone follow-up at 3-7 (first follow-up) and 40-55 hours (second follow-up)

Trial Locations

Locations (1)

Carolinas Medical Center; 🇺🇸 Charlotte, North Carolina, United States