NCT04135092No Longer Available不适用
Single Patient Protocol: A Phase II Study Using the Administration of Autologous T-Cells Genetically Engineered to Express T-Cell Receptors Reactive Against Mutated Neoantigens in a Patient With Metastatic Cancer Plus the Administration of Pembrolizumab
相关药物
试验速览
- 阶段
- 不适用
- 状态
- No Longer Available
研究概览
简要总结
Single Patient Expanded Access
详细描述
Background:
Please refer to National Cancer Institute Surgery Branch (NCI-SB) protocol 18-C-0049, Amendment F.
Objective:
Under Individual Patient Expanded Access, to treat a patient with metastatic prostate cancer with autologous peripheral blood lymphocytes (PBL) that have been transduced with genes encoding T-cell receptors that recognize the mutated TP53 shared oncogene in the autologous cancer.
Eligibility:
研究设计
- 研究类型
- Expanded Access
入排标准
- 接受健康志愿者
- 否
入选标准
- •Measurable (per RECIST v1.1 criteria), metastatic prostate cancer.
- •Refractory to approved standard systemic therapy.
- •Ability of subject to understand and the willingness to sign a written informed consent document.
- •Willing to sign a Durable Power of Attorney Form.
- •Willing to practice birth control from the time of enrollment on this study and for four months after treatment.
- •Subject must be co-enrolled on protocol 03-C-0277.
排除标准
- •Not applicable.
研究者
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