Effects of PEEP in Brain Injury Patients
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 40
- 试验地点
- 2
- 主要终点
- Improvement of respiratory function with PEEP
研究概览
简要总结
The hypothesis is that brain injury patients have alterations of the respiratory system related to intraabdominal pressure. Furthermore application of moderate levels of PEEP may improve respiratory function in these patients.
详细描述
We investigate the mechanical properties of the respiratory system, partitioned into its lung and chest wall components, the functional residual capacity, the gas-exchange and alveolar recruitment in brain injured patients.
The measurements will be performed under sedation at different levels of PEEP. The following groups will be included: a) control patients withot lung injury and brain injury; b) brain injured patients without lung injury within the first 72 hours; c) brain injured patients without lung injury after 72 hours; d) brain injured patients with lung injury. Brain injury was defined as primary or secondary. Respiratory functional data will be related to intra-abdominal pressure.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Male and Female
- •Age > 18 yrs
- •Mechanical ventilation
- •No smoker
- •No lung injury at entry
- •Brain injury (traumatic or postoperative or spontaneous bleeding) in brain injury group
排除标准
- •Pregnancy
- •Hemodynamic instability
- •Immunodepression
结局指标
主要结局
Improvement of respiratory function with PEEP
时间窗: 30 min
次要结局
- Relations of respiratory mechanics (lung and chest wall) with intraabdominal pressure(30 min)