Airway Effects of PEEP During Anesthesia Induction.

Not Applicable

• Conditions: Anesthesia Induction; Airway Management; Mask-ventilation; Positive End Expiratory Pressure

• Registration Number: NCT02920879
• Lead Sponsor: Region Örebro County

Brief Summary

This study investigates airway effects of PEEP during maskventilation at anesthesia induction. Four patient groups will be ventilated with different PEEP and driving pressures to evaluate time to open airway after start of positive pressure maskventilation during anesthesia induction.

Detailed Description

The use of continuous positive pressure (CPAP/PEEP) during pre-oxygenation and mask-ventilation in patients undergoing anesthesia induction is increasing. Continuous positive pressures have several respiratory benefits with well-documented data on both spontaneously breathing patients and intubated patients. However the effects of PEEP on anesthetized patients during mask-ventilation is poorly investigated. In a previous trial the that the investigators conducted, a PEEP-level of 10 cmH2O during mask ventilation after anesthesia induction surprisingly delayed time to alveolar ventilation compared to ZEEP. In order to investigate this phenomenon, four groups of patients will be compared during preoxygenation and mask ventilation after anesthesia induction.

Each group consisting of 30 patients will be pre-oxygenated and mask ventilated with different CPAP/PEEP levels and different driving pressures. Time to open airway is measured as number of respiratory cycles until detection of CO2 on the capnograph.

Study Timeline

• Status Verified: 2016-09
• Study First Submitted: 2016-09-28
• Study First Submitted QC: 2016-09-28
• Study First Posted: 2016-09-30
• Last Update Submitted: 2016-09-30
• Study Start: 2016-10
• Last Update Posted: 2016-10-03
• Primary Completion: 2017-02

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

1. ≥ 18- ≤ 65 years male or female.
2. Elective surgery under general anesthesia
3. ASA-classification 1-3
4. Signed and dated informed consent

Exclusion Criteria

1. BMI > 30
2. Predicted difficult mask-ventilation
3. Known hiatus hernia or GERD

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Time to open airway	20 minutes	Time to open airway depending on ventilatory settings