The Effects of Dexmedetomidine and Tracheal Intubation on Heart Rate Variability and QTc Interval
Not Applicable
Completed
- Conditions
- Anesthesia, General
- Interventions
- Drug: 0.5 mcg/kg IV infusion for 10 min, 1.0 mcg/kg IV infusion for 10 min
- Registration Number
- NCT01584570
- Lead Sponsor
- Yonsei University
- Brief Summary
The purpose of this study is to investigate effect of dexmedetomidine and tracheal intubation on heart rate variability and QTc interval.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 80
Inclusion Criteria
- patient who are regarded as ASA class I
- age 20 to 60
- patient scheduled for Intubation for surgery
Exclusion Criteria
- QTc interval > 440 ms
- arrythmia
- Patient who is taking a medicine which effects QTc interval
- HTN
- DM
- renal disease
- hepatic disease
- pregnant
- illiterate
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description D 0.5 group 0.5 mcg/kg IV infusion for 10 min, 1.0 mcg/kg IV infusion for 10 min Dexmedetomidine 0.5 ug/kg + Propofol + Sevoflurane+ Vecuronium Control 0.5 mcg/kg IV infusion for 10 min, 1.0 mcg/kg IV infusion for 10 min fentanyl 1 mcg/kg before induction D 1.0 group 0.5 mcg/kg IV infusion for 10 min, 1.0 mcg/kg IV infusion for 10 min Dexmedetomidine 1.0 ug/kg + Propofol + Sevoflurane+ Vecuronium
- Primary Outcome Measures
Name Time Method Change of QTc interval T1 (at rest), T2 (5 min after dexmedetomidine infusion), T3 (just before intubation), T4(1 min after intubation), T5(2 min after intubation), T6(3min after intubation) T1- baseline, T2- to evaluate the effect of dexmedetomidine on QTc interval, T3- to evaluate QTc interval just before intubation, T4,5,6 - to evaluate QTc interval after intubation
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Severance hospital
🇰🇷Seoul, Korea, Republic of