Efficacy of Two Intermittent Subglottic Secretion

Not Applicable

• Conditions: Ventilator Associated Pneumonia
• Interventions: Procedure: Subglottic secretion aspiration; Procedure: Subglottic secretion lavage combined with aspiration

• Registration Number: NCT03871985
• Lead Sponsor: The First Hospital of Jilin University

Brief Summary

The purpose of this study is to determine the efficacy of intermittent subglottic secretion lavage combined with aspiration preventing ventilator associated pneumonia in patients with severe neurological disease

Detailed Description

Ventilator-associated pneumonia (VAP) is a common and serious complication of mechanical ventilation. Many studies have shown that the accumulation of subglottic secretions above the endotracheal cuff plays an important role in the pathogenesis of VAP. Subglottic secretion drainage (SSD) has been shown to be associated with a lower incidence of VAP in previous meta-analyses. Most studies in past reported that in the group of patients in whom endotracheal tube (ETT) was used and subglottic secretion drainage was applied compared to the group without subglottic secretion drainage.Very few studies compared two different methods of SSD,such as subglottic secretion lavage combined with aspiration or pure aspiration.The tubes need frequent cleaning as they often get blocked, especially the draining duct. This may be the reason why they are not commonly applied. However,subglottic secretion lavage combined with aspiration can reduce the incidence of tube blockage.So The purpose of this study is to determine the efficacy of intermittent subglottic secretion lavage combined with aspiration preventing ventilator associated pneumonia in patients with severe neurological disease.

Study Timeline

• Status Verified: 2018-12
• Study First Submitted: 2019-02-19
• Study First Submitted QC: 2019-03-11
• Last Update Submitted: 2019-03-11
• Study First Posted: 2019-03-12
• Last Update Posted: 2019-03-12
• Study Start: 2019-03-15
• Primary Completion: 2019-12-30
• Study Completion: 2020-01-15

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 234

Inclusion Criteria

• patients aged between 18 and 80 years requiring mechanical ventilation for more than 72 hours with placement of an ETT( equipped with a dorsal suction catheter for subglottic secretion drainage)

Exclusion Criteria

• Exclusion criteria were patients endotracheal intubation was performed before admission, history of HIV, immunosuppression, leukopenia, patient refusal,and

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Pure aspiration	Subglottic secretion aspiration	Intermittent subglottic secretions aspiration
Lavage combined with aspiration	Subglottic secretion lavage combined with aspiration	Intermittent subglottic secretions lavage combined with aspiration

Primary Outcome Measures

Name	Time	Method
Incidence of ventilator-associated pneumonia	through study completion, an average of 10 months	is pneumonia that occurs when an artificial airway is established and mechanically ventilated

Secondary Outcome Measures

Name	Time	Method
Incidence of draining duct blockage	through study completion, an average of 10 months	If mucus flow stopped during subglottic suctioning with a sudden increase of the negative pressure in the proximal port of the suction suggesting a probable occlusion