Comparative efficacy study of periarticular multimodal analgesic injection containing corticosteroid o rnonsteroidal anti-inflammatory drugs in total knee arthroplasty; randomized control trial
Phase 4
Recruiting
- Conditions
- Total knee arthroplasty,periarticular injection in total knee replacement,ketorolac,Post-operation pain in total knee replacement (primary osteoarthritis)morphine consumption,triamcinolone acetonide,
- Registration Number
- TCTR20191221006
- Lead Sponsor
- none
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 52
Inclusion Criteria
Patient is
1) Primary osteoarthritis of knee, Kellgren and Lawrence system :grade 3, 4
2) varus deformity < 15 degree
3) American Society of Anesthesiologists (ASA) : classs II or III
Exclusion Criteria
Patient is
1) cannot spinal anesthesia
2) poor controlled diabetic mallitus
3) renal insufficiency : GFR < 30 mL/min
4) Cardiovascular thrombotic event eg. myocardial infarction,thrombotic stroke
5)Drug allergy (cefuroxime, bupivacaine, epinephrine, , ketorolac, triamcinolone acetonide, transamine, cefuroxime,morphine,parecoxib, paracetamol, pregabalin, aspirin)
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Amount of morphine consumption after total knee replacement 0,24,48,72 hrs. IV Pain controlled anesthsia (mg)
- Secondary Outcome Measures
Name Time Method evel of pain after total knee replacement 0,24,48,72 hrs. Visual analog scale (0-100 mm)