Comparison of intra-articular injection of dexmedetomidine and triamcinolone in improving knee pain and function in patients with primary knee osteoarthritis.

Phase 2

Recruiting

Conditions: Osteoarthritis of knee.
Bilateral primary osteoarthritis of knee
M17.0

Registration Number: IRCT20130518013364N11

Lead Sponsor: Shahid Beheshti University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 60

Inclusion Criteria

Age over 40 years
Presence of knee pain for more than 3 months
Radiological findings confirming knee osteoarthritis based on American College of Rheumatology (ACR) criteria

Exclusion Criteria

Unwillingness to participate in the study
Patients with a history of knee surgery
Patients with lower limb deformity and contracture
Patients with lower limb neuromuscular disease
Patients with acute lumbar pathology
Injection of steroid drugs during the last two months
History of inflammatory rheumatoid arthritis
History of recent infection in the knee
Diabetes
Pregnancy
Breastfeeding
BMI> 35
Candidate patients for knee surgery
The presence of knee deviation (Varus or valgus more than five degrees) which was confirmed by three joint view
The presence of radicular pain
Taking anticoagulants
Arthritis after trauma
History of intra-articular injection of the knee during the last 12 months
Allergy to any of the drugs used
Chronic systemic disease
Psychiatric illness
Severe osteoarthritis with grade more than III
Hepatitis
Cytomegalovirus infection
Having syphilis
Having osteomyelitis
Drug and alcohol abuse
Having AIDS

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Pain. Timepoint: At the beginning of the study (before the start of the intervention) and one and three months after. Method of measurement: Visual analog scale.;The total score of the KOOS questionnaire. Timepoint: At the beginning of the study (before the start of the intervention) and one and three months after. Method of measurement: Based on asking the patient and scoring each of the items.

Secondary Outcome Measures