Prolotherapy in Knee Osteoarthritis

Not Applicable

Recruiting

• Conditions: Knee Osteoarthritis.; Bilateral primary osteoarthritis of knee

• Registration Number: IRCT20180623040209N1
• Lead Sponsor: Shiraz University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 11 September 2018

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Negative Ballottement Test
Negative Fluid Wave Test
Age from 38 to 70 years in both sexes
Suffering from Knee Osteoarthritis with effusion based on clinical criteria of American College of Rheumatology
Suffering from grades 2 and 3 of Knee Osteoarthritis based on Kellgern and Lawrence Grading Scale
Complain of knee pain at least for three months before study
Knee crepitation at least for three months before study
Knee joint stiffness at least for three months before study

Exclusion Criteria

Foot deformity
Sever Genu Valgum
Any infection affecting the knee skin
Any intra or peri articular injection for the last three months before the study
History of knee joints rheumatic or inflammatory disease
History of total knee arthtoplasty
Uncontrolled diabetes with HbA1c more than 7.5%
BMI more than 42
History of knee trauma or fracture for the last three months before the study
History of acute lumbosacral radiculopathy or peripheral neuropathy
History of cancer
Bleeding disorders
Pregnancy
Severe Genu Varum

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Pain. Timepoint: Before first injections, 4 and 8 weeks after first injection. Method of measurement: Visual Analog Scale (VAS).;Function. Timepoint: Before first injections, 4 and 8 weeks after first injection. Method of measurement: The WOMAC questionnaire consists of 24 items divided into 3 sub scales: Pain (5 items): during walking, using stairs, in bed, sitting or lying, and standing. Stiffness (2 items): after first waking and later in the day. Physical Function (17 items): stair use, rising from sitting, standing, bending, walking, getting in/out of a car, shopping, putting on/taking off socks, rising from bed, lying in bed, getting in/out of bath, sitting, getting on/off toilet, heavy household duties, light household duties.