An Investigation into the Efficacy of Intra-articular Injection of Botulinium Toxin versus Steroid on Pain and Function of Patients with Knee Osteoarthritis
- Conditions
- knee osteoarthritis.Gonarthrosis [arthrosis of knee]
- Registration Number
- IRCT2017103013442N20
- Lead Sponsor
- Physical Medicine and Rehabilitation Department of Shahid Beheshti University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 40
Inclusion critetia: Confirmed knee-osteoarthritis patients based on American College of Rheumatology (ACR) criteria with ages ranging from 40 to 75 years; more than 3 months symptoms resistant despite the conservative treatment; grade 2 or 3 according to KLS system in plain x-ray film.
Exclusion criteria: Infection and active wound in knee; Gout or psudogout; neuromuscular illnesses; Pregnancy or breast-feeding; any history of intra articular injection over the past 3 months; Acute trauma of knee; Recent physiotherapy during last 3 months; Genuvarum or valgum more than 20 degrees; Radioculophathy; BMI=35; Hx of allergy to Botulinium Toxin; Systemic illnesses like diabetes melitus, immunodeficiency, and vascular collagen diseaes; prior history of cancer or active malignant lesions; ages below 40 years or above 75 years.
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Knee Pain. Timepoint: Before intervention and 8 & 24 weeks after injection. Method of measurement: WOMAC questionnaire.
- Secondary Outcome Measures
Name Time Method Pain. Timepoint: Before intervention and 8 & 24 weeks after injection. Method of measurement: VAS questionnaire.;Joint Stiffness. Timepoint: Before intervention and 8 & 24 weeks after injection. Method of measurement: WOMAC questionnaire.;Patient Function. Timepoint: Before intervention and 8 & 24 weeks after injection. Method of measurement: WOMAC questionnaire.