Assessment of Knee Cartilage Quality at 7T MRI with Glycosaminoglycan Chemical Exchange Saturation Transfer (gagCEST)

Completed

• Conditions: cartilage degeneration; Osteoarthritis; 10043237

• Registration Number: NL-OMON42475
• Lead Sponsor: Orthopedie

Brief Summary

Trial ended prematurely

Detailed Description

Not available

Study Timeline

• Study Completion: 2018-08-01
• Results First Posted: 2020-10-26
• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 19

Inclusion Criteria

Patients who are planned to undergo a total knee arthroplasty because of severe cartilage damage or patients who are planned to undergo an arthroscopy because of suspected cartilage damage.

Exclusion Criteria

Patients with previous knee surgery. Patients with other prostheses or metal objects/hardware. Patients with contra-indications to MRI scanning according to hospitals 7T MRI screening guideline of the UMC Utrecht

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Validation of the gagCEST protocol with histology as golden standard<br /><br>Detection of (or a reproducible gradation of) the cartilage defects based on<br /><br>the gagCEST MRI measurements for (early) diagnosis and monitoring of<br /><br>osteoarthritis. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Relate the cartilage thickness on the clinically relevant morphological MRI<br /><br>with the MTR asymmetry spectrum based on the gagCEST MRI. </p><br>