7T Sodium MRI of healthy and osteoarthritic cartilage of the knee

Recruiting

• Conditions: degenerative joint disease; Osteoarthritis; wear and tear of the joint; 10043237

• Registration Number: NL-OMON38455
• Lead Sponsor: Moleculaire Epidemiologie

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 200

Inclusion Criteria

Patients: people who are selected for knee joint replacement
Age-matched controls: people who are OA symptom free
Healthy volunteers: people who are OA symptom free

Exclusion Criteria

Contra-indications for 7T MRI scanning
No consent
No family

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>1) A curve that describes normal sodium concentration in knee cartilage over a<br /><br>broad age range. This curve a a normal curve that can be used to detect early<br /><br>OA using sodium-MRI.<br /><br>2) Fundamental insight into the mechanism of OA and cartilage degeneration by<br /><br>comparing sodium concentrations in cartilage in different pools (bound to PG<br /><br>and free in solution).<br /><br>3) Development of a gold standard for sodium concentration measurements in vivo<br /><br>in cartilage by comparing sodium-MRI with ex vivo concentration measurements of<br /><br>post-surgery obtained cartilage.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>If the primary outcomes are of sufficient quality then these techniques can be<br /><br>used for the development of new OA treatments.</p><br>