Osteoarthrosis on 7.0T Magnetic Resonance Imaging

Recruiting

• Conditions: Osteoarthrosis; MRI

• Registration Number: NCT05343104
• Lead Sponsor: Chinese PLA General Hospital

Brief Summary

This clinical trial studies the use of 7-Tesla (7T)and 3T magnetic resonance imaging (MRI) in detecting osteoarthrosis. 7T MRI has increased detection sensitivity, including more accurate lesion delineation, higher inter-rater agreement. Diagnostic procedures such as 7T MRI may help ultimately improved diagnostic and therapies confidence to inform decision making than standard 3T MRI.

Detailed Description

7T MRI increased detection sensitivity, attain superior anatomic resolution, higher spatial and spectral specificity of advanced quantitative techniques, and shorter scan times than 3T MRI. When applied clinically, these benefits translate to increased detection sensitivity, and ultimately improved diagnostic and therapies confidence to inform decision making. This study aim to detect the image characteristics and diagnostic accuracy of osteoarthrosis on 7T MRI.

Study Timeline

• Status Verified: 2022-04
• Study Start: 2022-04-01
• Study First Submitted: 2022-04-19
• Study First Submitted QC: 2022-04-22
• Last Update Submitted: 2022-04-22
• Study First Posted: 2022-04-25
• Last Update Posted: 2022-04-25
• Primary Completion: 2024-05-31
• Study Completion: 2025-05-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Age≥18 and ≤80
• Having no contraindications against MRI
• Clinically stable

Exclusion Criteria

• Age#18 or #80
• Pregnancy and other contraindication to MRI scan
• Informed consent not obtained

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The thickness of the cartilage of patellar on 7T MRI scan	baseline	Thickness of different part of the cartilage of patellar measured based on axial PD images
The T2 mapping value of the patellar cartilage on 7T MRI scan	baseline	T2 relaxation times of the patellar cartilage measured based on T2 mapping
The abnormal signal in the infrapatellar fat pad	baseline	The exist of abnormal signal in the infrapatellar fat pad detected based on sagittal PD images

Secondary Outcome Measures

Name	Time	Method
Signal change of the patellar chondral before and after rehabilitation	1 month after rehabilitation	The correlation between abnormal change of the patellar chondral and reaction 1 month after rehabilitation
Signal change of the infrapatellar fat pad before and after rehabilitation	1 month after rehabilitation	The correlation between abnormal signal in the infrapatellar fat pad and reaction 1 month after rehabilitation

Trial Locations

Locations (1)

Chinese PLA General Hospital; 🇨🇳 Beijing, China