Metabolomics of Insomnia-Related Hyperarousal
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 32
- 试验地点
- 1
- 主要终点
- Number of Metabolites Elevated Relative to the Other Group.
研究概览
简要总结
Individuals with insomnia have been shown to have higher overall metabolic rates compared to good sleepers, but it is not known which metabolic processes are involved. The goal of this study is to compare a wide array of metabolic processes in 15 people with insomnia and 15 good sleepers. We hypothesize that there will be distinct metabolic processes that are functioning differently in those with insomnia.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 25 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Criteria for primary insomnia:
- •subjective complaint of difficulty initiating or maintaining sleep, waking up too early or nonrestorative sleep
- •daytime consequences as a result of the poor sleep
- •duration of at least 1 month
- •sleep disturbance is not secondary to a medical or psychiatric condition
- •Criteria for good sleepers:
- •subjective report of consistent good sleep
排除标准
- •significant medical or psychiatric illness
- •diagnosis of a sleep disorder other than insomnia
- •women who have been pregnant or lactating in the past 6 months
- •non-fluency in spoken or written English
- •Current shift work defined as working during the evening or night shift
- •Current use of medications that affect sleep
结局指标
主要结局
Number of Metabolites Elevated Relative to the Other Group.
时间窗: 48 hours
Metabolomics analysis of blood samples were carried out using Spectroscopy. This approach allows for rapid, unbiased and quantitative metabolic profiles ('fingerprints) to be acquired. A total of 70 metabolites were measured and compared between individuals with insomnia and good sleepers.
次要结局
- Sleep Efficiency Percentage on Overnight Sleep Study(1 night)