Dynamic Myocardial Perfusion Imaging by 320 Multidetector Computed Tomography

Completed

• Conditions: Coronary Heart Disease
• Interventions: Radiation: Computed tomography scan

• Registration Number: NCT01368237
• Lead Sponsor: University of Edinburgh

Brief Summary

Recent advances in technology have resulted in the development of scanners that can image the heart blood vessels within 10 to 20 minutes but without the need for admission to hospital or insertion of catheters. Further advances in technology allow the visualisation of both the blood vessels and the supply of blood to the heart muscle. Here we propose to assess the latest and most powerful computed tomography scanner and compare it to magnetic resonance and conventional coronary angiography.

Detailed Description

Not available

Study Timeline

• Study Start: 2006-05
• Study First Submitted: 2011-06-06
• Study First Submitted QC: 2011-06-06
• Study First Posted: 2011-06-07
• Primary Completion: 2014-06
• Status Verified: 2014-10
• Study Completion: 2017-01-01
• Last Update Submitted: 2018-06-21
• Last Update Posted: 2018-06-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 51

Inclusion Criteria

• referred for invasive coronary angiography because of suspected coronary heart disease

Exclusion Criteria

• inability or unwillingness to undergo computed tomography or magnetic resonance imaging
• renal failure (serum creatinine >200 micromol/L or estimated glomerular filtration rate <30 mL/min)
• hepatic failure
• allergy to iodinated contrast or gadolinium
• pregnancy
• contraindication to adenosine infusion
• inability to give informed consent
• inability to perform fractional flow reserve during invasive coronary angiography

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Patients	Computed tomography scan	Patients awaiting invasive coronary angiography

Primary Outcome Measures

Name	Time	Method
Myocardial perfusion defects defined qualitatively by trained observers and quantitatively by computer software	1 month	The primary outcome measure is to establish whether 320-multidetector computed tomography can identify myocardial perfusion defects as compared to the gold standards of 3Tesla magnetic resonance imaging and fractional flow reserve measured during invasive coronary angiography.

Secondary Outcome Measures

Name	Time	Method
Identification of infarction qualitatively by trained observers	1 month	Our secondary outcome measures are to assess the performance of 320-multidetector computed tomography in the detection of infarction in comparison to those obtained with 3Tesla cardiac magnetic resonance imaging.
Identification of regional wall motion abnormalities quantitatively by computer software	1 month	Our secondary outcome measures are to assess the performance of 320-multidetector computed tomography in the detection of regional wall motion abnormalities in comparison to those obtained with 3Tesla cardiac magnetic resonance imaging.
Identification of infarction qualitatively by computer software	1 month	Our secondary outcome measures are to assess the performance of 320-multidetector computed tomography in the detection of infarction in comparison to those obtained with 3Tesla cardiac magnetic resonance imaging.
Identification of regional wall motion abnormalities qualitatively by trained observers	1 month	Our secondary outcome measures are to assess the performance of 320-multidetector computed tomography in the detection of regional wall motion abnormalities in comparison to those obtained with 3Tesla cardiac magnetic resonance imaging.

Trial Locations

Locations (1)

Royal Infirmary of Edinburgh; 🇬🇧 Edinburgh, Scotland, United Kingdom