Cardioprotective and neuroprotective effects of Dexmedetomidine in patients undergoing cardiac surgery by down-regulation of miR-499 and up-regulation of miR-93: double-blinded RCT
Not Applicable
Active, not recruiting
- Conditions
- none
- Registration Number
- TCTR20180912005
- Lead Sponsor
- Ratchadapiseksompoj
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Active, not recruiting
- Sex
- All
- Target Recruitment
- 94
Inclusion Criteria
patients undergoing cardiac surgery
ASA physical status I-III
Exclusion Criteria
1) drug allergy
2) Preoperative LVEF ≤ 30%
3) BMI ≥ 35 km/m 2
4) Preoperative mean arterial pressure < 60 mmHg
5) Preoperative heart rate < 45/min
6) Impaired renal function (serum creatinine > 1.5 mg/dl
in female and 2 mg/dl in male)
7) Active liver disease
8) history or active cerebrovascular and neurological disease
9) psychologic problems
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method % proportional of miR499 postoperative PCR,% proportional of miR93 postoperative PCR,survival rate postoperative years
- Secondary Outcome Measures
Name Time Method inotropes dosage postoperative mcg/kg/min,ICU stay postoperative hours,hospital stay postoperative days,survival rate postoperative years