Accelerated Repetitive Transcranial Magnetic Stimulation (rTMS) of the Dorsolateral Prefrontal Cortex for the Reduction of Craving in Nicotine Dependent Individuals

Medical University of South Carolina1 site in 1 country5 target enrollmentJanuary 1, 2018

ConditionsNicotine Use Disorder Nicotine Dependence

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Nicotine Use Disorder
Sponsor: Medical University of South Carolina
Enrollment: 5
Locations: 1
Primary Endpoint: Tolerability Measured by Percent of Participants Completing the rTMS Course
Status: Terminated
Last Updated: 6 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The purpose if this study is to determine if five treatments of repetitive transcranial magnetic stimulation (rTMS) can reduce craving for cigarettes in smokers. rTMS uses magnetic pulses to stimulate the brain and is currently approved for the treatment of major depressive disorder.

Registry

clinicaltrials.gov

Start Date

January 1, 2018

End Date

December 12, 2018

Last Updated

6 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

Medical University of South Carolina

Responsible Party

Principal Investigator

David Friedrich

Resident Physician

Medical University of South Carolina

Eligibility Criteria

Inclusion Criteria

•Outpatient Adults aged 18-70
•Cigarette Smokers smoking at least 1 pack (20 cigarettes a day) with current smoking status confirmed by exhaled CO reading of \>10ppm day of visit.
•Ability to provide informed consent
•Exclusion Criteria
•Current treatment with varenicline or bupropion
•Currently making a smoking quit attempt (not currently smoking).
•Current treatment with an antidepressant, anti-convulsant, anxiolytic, antipsychotic or mood stabilizer.
•Current episode of major depression determined by MINI interview.
•Current or past history of schizophrenia, schizoaffective disorder, anorexia nervosa, bulimia or bipolar disorder as determined by MINI.
•Current daily consumption of alcohol or current alcohol use disorder.

Exclusion Criteria

Not provided

Outcomes

Primary Outcomes

Tolerability Measured by Percent of Participants Completing the rTMS Course

Time Frame: 1 day (single visit)

Percent of participants completing the 5 session rTMS course. Hypothesize \>75% of participants will complete the 5 treatments.

Decrease in Cue Induced Nicotine Craving

Time Frame: During the one day visit

Nicotine craving evaluated using Questionnaire on Smoking Urges- Brief (QSU-B) questions modified to a 0-100 analog rating. Higher scores meaning a higher level of craving.