Predictors of Sepsis - Pred Sep
- Conditions
- I63.5A41Cerebral infarction due to unspecified occlusion or stenosis of cerebral arteriesOther sepsis
- Registration Number
- DRKS00003392
- Lead Sponsor
- Klinik für Neurologie
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 287
Inclusion Criteria
Ischemic infarction in the territory of the middle cerebral artery.
Age = 18.
NIH stroke score NIHSS > 8.
Exclusion Criteria
Existing infections at admission.
History of previous strokes.
Cardiogenic arrhythmias.
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Development of infection within the subacute phase (day 1-5) of the stroke.<br>Infection is defined according to the PANTHERIS study:<br>- Pneumonia is defined as presence of at least one of the A and one of the B criteria: A) abnormal respiratory examination, pulmonary infiltrates in chest X-Ray; B) productive cough with purulent sputum, microbiological cultures from lower respiratory tract or blood cultures, leukocytosis, and elevation of C-reactive protein (CRP). <br>- Urinary tract infection is defined as the presence of two of the following criteria: fever (>38.0 °C), urine sample positive for nitrite, leucocyturia, and significant bacteriuria.<br>- Infection is also diagnosed if temperature is above 38.0°C on at least 2 determinations with additional leucocytosis and positive blood cultures, but no determined focus. <br>
- Secondary Outcome Measures
Name Time Method Development of SIRS and severe sepsis in the subacute phase (day 1-5) after Stroke and functional outcome after 3 months.<br>-SIRS (criteria I) is defined according to Guidelines of the German Sepsis Society<br>-Severe Sepsis (criteria I, II and III) is defined according to Guidelines of the German Sepsis Society.<br>- Functional outcome is measured by lethality and neurological scores (modified Rankin Scale, Barthel Index, NIHSS).<br>