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临床试验/NCT04604886
NCT04604886Unknown不适用

The Consistency of Cardiac Output Measured by Pulmonary Artery Catheter and LiDCO in Cardiac Surgical Patients

Shanghai Zhongshan Hospital1 个研究点 分布在 1 个国家目标入组 40 人开始时间: 2020年9月30日最近更新:
适应症

试验速览

阶段
不适用
发起方
入组人数
40
试验地点
1
主要终点
Cardiac Output measurement after PLR

研究概览

简要总结

  1. To evaluate the consistency of cardiac output measured by pulmonary artery catheter and LiDCO in cardiac surgical patients
  2. To evaluate whether different hemodynamic monitoring methods can accurately detect the trend of cardiac output changes

详细描述

Close monitoring of cardiac output (CO), especially in patients before and after intervention(such as volume expansion, diuresis, vasoconstriction, vasodilation therapy), could help to adjust the treatment strategy in cardiac surgical patients. Pulmonary artery catherization (PAC) has been used for hemodynamic monitoring for more than four decades. In spite of its invasiveness, it remains the clinical reference method for the assessment of CO at the bedside. Nowadays, many less invasive alternatives, such as LiDCO Rapid Pulse Contour Analysis System (LiDCO Ltd., Cambridge, United Kingdom), are already available on market. However, consistency between different hemodynamic monitoring results still raise concern. And whether hemodynamic monitoring could accurately detect the changes of these parameters before and after intervention is an important issue in clinical practice. In this study, the investigators are going to collect CO and changes of CO from PAC and LiDCO before and after intervention (passive leg raising and dobutamine stress test) in cardiac surgical patients. Our resulst could provide important reference for cardiac surgical patients how to choose appropriate hemodynamic monitoring tools and how to interpret the results of hemodynamic monitoring.

研究设计

研究类型
Interventional
分配方式
Non Randomized
干预模型
Crossover
主要目的
Diagnostic
盲法
None

入排标准

年龄范围
18 Years 至 80 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • cardiac surgery
  • hemodynamic monitoring (PAC, LiDCO)
  • mechanical ventilation

排除标准

  • cardiac arrhythmia
  • moderate to severe aortic, mitral and tricuspid regurgitation

结局指标

主要结局

Cardiac Output measurement after PLR

时间窗: 1 minute after PLR

Cardiac Output measured after PLR

Baseline Cardiac Output measurement

时间窗: within1 minute at baseline position

Cardiac Output measured at baseline position (horizontal position)

Cardiac Output measurement after Dobutamine stress test

时间窗: 5 minutes after dobutamine stress test

Cardiac Output measured after dobutamine stress test

次要结局

未报告次要终点

研究者

发起方
Shanghai Zhongshan Hospital
申办方类型
Other
责任方
Sponsor

研究点 (1)

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