Efficacy Evaluation of Pitaya Ovule Extract on Skin
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- The change of skin elasticity
研究概览
简要总结
To assess the efficacy of Pitaya Ovule Extract on skin
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 20 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •20 to 65-year-old males or females
排除标准
- •Received medical cosmetic treatment (including cosmetic skin care, laser, fruit acid peeling, injection or plastic surgery, etc.) currently or within one month before the trial
- •Outdoor workers (exposed to the sun more than 5 hours a day)
- •People who are breastfeeding, pregnant or planning to become pregnant during the test (self-report)
- •People with heart, liver, kidney, endocrine and other major organic diseases (self-reported)
- •People who have undergone major surgery (according to medical history)
- •People who take drugs for a long time
- •People with mental illness
- •Students who are currently taking courses taught by the principal investigator of this trial
结局指标
主要结局
The change of skin elasticity
时间窗: Change from Baseline skin elasticity at 8 weeks
Cutometer® Dual MPA580 was utilized to measure skin elasticity. Units: arbitrary units
The change of skin pores
时间窗: Change from Baseline skin pores at 8 weeks
IRV skin analyzer was utilized to measure skin pores. Units: arbitrary units
The change of Advanced glycation end products of blood
时间窗: Change from Baseline AGEs at 8 weeks
Venous blood was sampled to measure AGEs
The change of skin texture
时间窗: Change from Baseline skin texture at 8 weeks
IRV skin analyzer was utilized to measure skin texture. Units: arbitrary units
The change of skin tone
时间窗: Change from Baseline skin tone at 8 weeks
IRV skin analyzer was utilized to measure skin tone. Units: arbitrary units
The change of Matrix metalloproteinases (MMP-2, MMP-9) of blood
时间窗: Change from Baseline MMPs at 8 weeks
Venous blood was sampled to measure MMPs
The change of L* (lightness) values
时间窗: Change from Baseline L* value at 8 weeks
Spectrophotometer SCM-108 was utilized to measure skin L\* value. Units: arbitrary units
The change of skin collagen density
时间窗: Change from Baseline skin collagen density at 8 weeks
DermaLab® Combo Ultrasound module was utilized to measure skin collagen density. Units: arbitrary units
The change of skin wrinkles
时间窗: Change from Baseline skin wrinkles at 8 weeks
IRV skin analyzer was utilized to measure skin wrinkles. Units: arbitrary units
The change of RAGE (receptor for advanced glycation end products) of blood
时间窗: Change from Baseline RAGE at 8 weeks
Venous blood was sampled to measure RAGE
次要结局
- The change of liver function biomarkers (AST, ALT) of blood(Change from Baseline liver function biomarkers at 8 weeks)
- The change of blood lipid profile(Change from Baseline blood lipid profile at 8 weeks)
- The change of fasting blood glucose level(Change from Baseline fasting blood glucose level at 8 weeks)
- The change of renal function biomarkers (creatinine, BUN) of blood(Change from Baseline renal function biomarkers at 8 weeks)
- Change from Baseline insulin level at 8 weeks(Change from Baseline insulin level at 8 weeks)