Vascular and Metabolic Responses to Exercise Training in Heart Failure With or Without Type 2 Diabetes

Duke University1 site in 1 countryFebruary 2012

ConditionsHeart Failure Type 2 Diabetes

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Heart Failure
Sponsor: Duke University
Locations: 1
Primary Endpoint: exercise capacity
Status: Withdrawn
Last Updated: 2 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The purpose of this study is to understand the differences in how patients with heart failure respond to exercise training compared to patients with heart failure and type 2 diabetes.

Detailed Description

The investigators will measure exercise capacity in patients with heart failure or heart failure plus type 2 diabetes prior to and following a 12-week exercise training program (5d/wk, 30 min/d, 60-75% VO2max) to determine whether improvements in exercise capacity in response to exercise training are mitigated in patients with combined heart failure plus type 2 diabetes.

Registry

clinicaltrials.gov

Start Date

February 2012

End Date

September 2014

Last Updated

2 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

Duke University

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•≥50 yr of age
•New York Heart Association class II-III CHF and ejection fraction ≤35%
•receiving optimal medical therapy
•sedentary (≤ 30 min/wk structured physical activity).
•Half of volunteers (n=30) will have a diagnosis of type 2 diabetes (CHF+T2D).

Exclusion Criteria

•changes in medication ≤6 wk prior to enrollment
•major cardiovascular event or procedure ≤6 wk prior to enrollment
•foot ulcers
•advanced neuropathy
•co-morbidities or other limitations that may interfere with or prevent volunteers from safely completing the exercise training
•fixed rate pacemaker
•type 1 diabetes mellitus