B-cells in stroke-associated infectio

Not Applicable

Completed

• Conditions: Acute stroke; Circulatory System

• Registration Number: ISRCTN55201674
• Lead Sponsor: Salford Royal NHS Foundation Trust

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2018-09-24
• Study Completion: 2022-03-20
• Last Update Posted: 5 August 2022

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 145

Inclusion Criteria

Stroke patients:
1. Age =18 years
2. Clinical diagnosis of middle cerebral artery (MCA) territory ischaemic stroke or haemorrhage stroke (primary intracerebral haemorrhage)
3. NIHSS =8
4. Swallowing difficulties identified on swallow screen performed within 24h of stroke admission
5. Capacity to give consent to blood sampling and follow-up OR availability of personal/professional consultee
6. Blood draw can be undertaken 24-48h after stroke onset (or time last seen well)

Non-stroke controls:
Aged over 18

Added 15/06/2020:
COVID-19 sub-study:
1. Age =18
2. Clinical diagnosis ischaemic stroke or haemorrhagic stroke (primary intracerebral haemorrhage; ICH) in any cerebral territory
3. Suspected or confirmed diagnosis of COVID-19 (either prior to stroke admission or within 7 days of stroke onset)*
4. NIHSS >2 (regardless of swallow status)
5. Capacity to give consent to participation or verbal declaration from personal consultee prior to blood sampling
6. Blood draw can be undertaken within 7 days of stroke onset (or time last seen well)

Exclusion Criteria

Stroke patients:
1. Stroke of other aetiology or unclear diagnosis (e.g. traumatic, stroke mimic)
2. Rapidly improving symptoms at the point of screening
3. History of infection treated with antibiotics at admission or in the preceding 6 weeks
4. Unlikely to survive or palliative care considered to be imminent

Non-stroke controls:
1. Previous stroke
2. Infection or antibiotic therapy in previous 6 weeks

Added 15/06/2020:
COVID-19 sub-study:
1. Stroke of other aetiology or unclear diagnosis (e.g. traumatic, stroke mimic)
2. Rapidly improving symptoms at the point of screening
3. Unlikely to survive or palliative care considered to be imminent

Study & Design

• Study Type: Observational
• Study Design: Not specified