Dose-dependent Effects of Second-hand Smoke on Vascular Function
Not Applicable
Completed
- Conditions
- Cardiovascular Disease
- Registration Number
- NCT01007760
- Lead Sponsor
- University of California, San Francisco
- Brief Summary
The purpose of this study is to determine the vascular effects of brief second-hand smoke exposure on normal healthy individuals.
- Detailed Description
Second-hand smoke remains a significant public health threat. Despite evidence to suggest that secondhand smoke contributes to adverse cardiovascular outcomes, little is known about the dose-dependent vascular effects of brief secondhand smoke exposure at low doses commonly encountered in the community. This study will investigate the acute vascular effects and dose-dependent biological mechanisms of secondhand smoke on endothelial function and oxidative stress.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 33
Inclusion Criteria
- Healthy non-smoking adults
Exclusion Criteria
- Reported Active Smoking
- History of diabetes, hypertension, chronic respiratory disease, coronary artery disease, prior myocardial infarction or heart failure
- Pregnancy or breastfeeding
- Current use of prescription drugs within 14 days of trial
- Reported significant passive smoke exposure or elevated cotinine levels
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Brachial Artery Flow-mediated dilation (FMD) Same day - before/after exposure
- Secondary Outcome Measures
Name Time Method Plasma measurement of asymmetric dimethylarginine (ADMA) and Nitrotyrosine levels Same day - before/after exposure
Trial Locations
- Locations (1)
UCSF San Francisco General Hospital
🇺🇸San Francisco, California, United States
UCSF San Francisco General Hospital🇺🇸San Francisco, California, United States