NCT01007760已完成不适用
Dose-dependent Biological Mechanisms of Second-hand Smoke on Endothelial Function and Oxidative Stress
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 33
- 试验地点
- 2
- 主要终点
- Brachial Artery Flow-mediated dilation (FMD)
研究概览
简要总结
The purpose of this study is to determine the vascular effects of brief second-hand smoke exposure on normal healthy individuals.
详细描述
Second-hand smoke remains a significant public health threat. Despite evidence to suggest that secondhand smoke contributes to adverse cardiovascular outcomes, little is known about the dose-dependent vascular effects of brief secondhand smoke exposure at low doses commonly encountered in the community. This study will investigate the acute vascular effects and dose-dependent biological mechanisms of secondhand smoke on endothelial function and oxidative stress.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy non-smoking adults
排除标准
- •Reported Active Smoking
- •History of diabetes, hypertension, chronic respiratory disease, coronary artery disease, prior myocardial infarction or heart failure
- •Pregnancy or breastfeeding
- •Current use of prescription drugs within 14 days of trial
- •Reported significant passive smoke exposure or elevated cotinine levels
结局指标
主要结局
Brachial Artery Flow-mediated dilation (FMD)
时间窗: Same day - before/after exposure
次要结局
- Plasma measurement of asymmetric dimethylarginine (ADMA) and Nitrotyrosine levels(Same day - before/after exposure)
研究者
研究点 (2)
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