Feasibility and Reproducibility of T1 Rho MRI in the Evaluation of Hip Cartilage

Not Applicable

Completed

• Conditions: Healthy Volunteers
• Interventions: Device: Hip cartilage MRI

• Registration Number: NCT02792010
• Lead Sponsor: Hospices Civils de Lyon

Brief Summary

Hip osteoarthritis is a frequent and invalidating disease. Early detection of cartilage modifications could provide better patient treatment. The T1rho MRI sequence allows the quantification of the cartilage signal that is correlated to modifications of the cartilage matrix, notably of the proteoglycans. The primary objective is to evaluate normal values of hip cartilage in vivo using T1rho MRI in healthy subjects and the reproducibility of the measurements. T1rho and T2 mapping sequences were acquired twice during the same session with 30 minutes interval to see if values were modified after a 30 minutes delay in a supine position. The secondary objective was to assess the correlation between T1rho and T2 values.

Detailed Description

Not available

Basic Information
|
Recruitment & Eligibility
|
Study & Design
|
Trial Locations

Study Timeline

• Study Start: 2015-05
• Primary Completion: 2016-01
• Study Completion: 2016-01
• Status Verified: 2016-05
• Study First Submitted: 2016-05-26
• Study First Submitted QC: 2016-06-01
• Study First Posted: 2016-06-07
• Last Update Submitted: 2017-01-11
• Last Update Posted: 2017-01-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 31

Inclusion Criteria

• BMI <30
• Accepting to participate in the study and signed the written informed consent
• Covered by a health insurance system

Read More

Exclusion Criteria

• Pregnant woman or risk of pregnancy
• MRI contraindication
• Protected adults
• Language barrier
• Previous or current hip pain

Read More

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
T1rho MRI	Hip cartilage MRI	Patients included had hip cartilage MRI with acquisition of T1rho MRI sequence.

Primary Outcome Measures

Name	Time	Method
Quantification of the cartilage signal at T1rho MRI	Up to one month after inclusion (Visit 1)	T1rho values of total hip cartilage and for each sub-region (mean, standard deviation, histogram)

Secondary Outcome Measures

Name	Time	Method
Quantification of the cartilage signal at T1rho MRI	15 (+/- 7) days after visit 1 (Visit 2)	T1rho values of total hip cartilage and for each sub-region (mean, standard deviation, histogram)
Quantification of the cartilage signal at T2 MRI	15 (+/- 7) days after visit 1 (Visit 2)	T2 values of total hip cartilage and for each sub-region (mean, standard deviation, histogram)
Presence of cartilage lesions	15 (+/- 7) days after visit 1 (Visit 2)	Morphological sequence to determine focal lesions

Trial Locations

Locations (1)

Hospices Civils de Lyon - Hôpital Edouard Herriot Pavillon B Radiologie; 🇫🇷 Lyon, France