Heparin sensitivity in cardio-thoracic surgery: the effect of surgical trauma

Completed

• Conditions: cardiac valve surgery; Coronary artery bypass graft surgery; 10007593

• Registration Number: NL-OMON36891
• Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 78

Inclusion Criteria

Patients scheduled for coronary artery bypass grafting (CABG) or cardiac valve surgery with cardiopulmonary bypass
Age 18-85 years
Informed consent

Exclusion Criteria

Re-operations
Emergency operation
Patients with insulin-dependent diabetes mellitus
Patients with a history of hematologic, hepatic or renal diseases
Patients with Body Mass Index (BMI) over 30 kg/m2
Patients with anemia (Hb < 5.5 mmol/l)

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Difference in heparin sensitivity between patients undergoing CABG and cardiac<br /><br>valve surgery<br /><br>Differences in rotational thromboelastometry and platelet aggregometery between<br /><br>groups<br /><br>Heparin and protamine dosing</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Classical coagulation tests (aPTT, PT, platelet count)<br /><br>Hemoglobin, hematocrit<br /><br>Demographic variables, fluid intake, perioperative medication<br /><br>Surgical characteristics<br /><br>Microparticles</p><br>