OxLith: exploration of the short-term physical and psychological effects of lithium in mood instability

niversity of Oxford (UK)0 个研究点目标入组 40 人开始时间: 2015年1月21日最近更新: 2022年6月27日

适应症

试验速览

•1. Willing and able to give informed consent to participate in the trial
•2. Meeting criteria for bipolar disorder
•3. Clinical complaint of significant mood instability
•4. Clinical uncertainty about the prescription of lithium
•5. No clear indication for alternative treatment
•6. Pre-treatment blood test results acceptable for initiation of lithium
•7. Willing and able to comply with all trial requirements (assessed by a psychiatrist)
•8. Willing to allow his or her General Practitioner and, if appropriate, psychiatrist to be notified of participation in the trial

•1. Any contraindication to lithium
•2. Currently taking any psychotropic drug that cannot be withdrawn
•3. Clinically significant alcohol or substance use
•4. Requiring immediate treatment for an acute mood episode such that placebo would be inappropriate
•5. Female and pregnant, lactating or currently planning a pregnancy
•6. Female of child-bearing potential not willing to use effective contraception
•7. Participation in another research trial involving an investigational medicinal product in the past 12 weeks
•8. Judged to be at significant immediate risk of suicide/self-harm
•(Participants with contraindication to one or both brain scans will be excluded from that part of the trial)

发起方

niversity of Oxford (UK)