Reactivation of herpesviruses and cardiovascular and cerebrovascular risk factors in an African ART populatio

Not Applicable

Completed

• Conditions: Cardiovascular and cerebrovascular disease; Circulatory System

• Registration Number: ISRCTN42862937
• Lead Sponsor: GlaxoSmithKline

Brief Summary

2019 Protocol article in https://pubmed.ncbi.nlm.nih.gov/31515413/ protocol (added 05/10/2020)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2018-05-15
• Study Completion: 2021-11-30
• Last Update Posted: 23 May 2022

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 1090

Inclusion Criteria

1. Aged => 35 years
2. Resident in Blantyre
3. HIV-infected patients must further be ART-naïve or initiated ART <10 days prior to enrolment
4. Initiating standard first-line ART (in Malawi this is: TDF/3TC/EFV)
5. Adult controls must further be HIV uninfected

Exclusion Criteria

1. Clinical history of CVD/CBD
2. Pregnant
3. Critically ill or have symptomatic anaemia at enrolment
4. Enrolled in an intervention study

Study & Design

• Study Type: Observational
• Study Design: Not specified