Effectiveness and Safety Of Add On- Nebulized MgSO4 with salbutamol and Salbutamol Alone in Bronchial Asthma Management in Children of 6-12 Years. A Randomized controlled Trial.

This study is a randomized parallel group active controlled trial conducted to evaluate the effectiveness and safety of add on nebulized magnesium sulfate in combination with salbutamol compared to salbutamol alone in the management of acute bronchial asthma in children aged 6 to 12 years. A total of 126 children diagnosed with acute bronchial asthma and requiring hospital admission will be enrolled and randomly allocated into two groups. The intervention group will receive nebulized magnesium sulfate 100 mg in combination with salbutamol 2.5 mg while the control group will receive nebulized salbutamol 2.5 mg with isotonic saline. Nebulization will be administered every 20 minutes for four doses using a jet nebulizer with oxygen. The primary outcome will be improvement in clinical severity score and peak expiratory flow rate. Secondary outcomes include duration of hospital stay and occurrence of adverse events. The study aims to generate evidence on the role of nebulized magnesium sulfate as an add on therapy in pediatric acute bronchial asthma.