NCT02170051
Completed
N/A
Improving Negative Symptoms of Psychosis In Real-world Environments
ConditionsSchizophrenia
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Schizophrenia
- Sponsor
- University of California, San Diego
- Enrollment
- 64
- Locations
- 1
- Primary Endpoint
- Clinical Assessment Interview for Negative Symptoms (CAINS)
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
This study will compare Cognitive Behavioral Social Skills Training-Compensatory Cognitive Training (CBSST-CCT) to a goal-focused supportive contact group to see which intervention better improves symptoms and functioning in people with schizophrenia.
Investigators
Elizabeth Twamley
Professor of Psychiatry
University of California, San Diego
Eligibility Criteria
Inclusion Criteria
- •MUST BE A RESIDENT OF BROADWAY HOME, SAN DIEGO, OR A SERVICE USER OF THE MEETING PLACE, ARETA CROWELL, OR PROJECT ENABLE.
- •Voluntary informed consent to participate
- •Age 18 to 65
- •DSM-IV diagnosis of schizophrenia or schizoaffective disorder based on MINI/SCID
- •Moderate-to-severe negative symptoms on the Clinical Assessment Interview for Negative Symptoms (CAINS total score \>19)
- •≥ 6th grade reading level on the Wide Range Achievement Test-4 Reading subtest (needed for reading treatment manual)
- •Stable on medications; no changes within 3 months prior to enrollment
Exclusion Criteria
- •Prior CBT, SST, or CCT in the past 5 years
- •Severe positive symptoms on the Positive and Negative Syndrome Scale (PANSS Delusions, Disorganization, Hallucinations, or Suspiciousness \>5)
- •Severe depression on the Calgary Depression Scale for Schizophrenia (CDSS \>8)
- •Ocular damage/disease/surgery/medications that affect pupil dilation
- •DSM-IV alcohol or substance dependence diagnosis in past 6 months based on the MINI or SCID
- •Level of care required interferes with outpatient therapy (e.g., hospitalized; severe medical illness) .
Outcomes
Primary Outcomes
Clinical Assessment Interview for Negative Symptoms (CAINS)
Time Frame: baseline, 12.5 weeks
Change in negative symptom severity at 12.5 weeks. Scores range from 0-52; higher values indicate greater severity.
Secondary Outcomes
- MATRICS Consensus Cognitive Battery (MCCB)(baseline, 12.5 weeks)
- UCSD Performance-based Skills Assessment-Brief (UPSA-B)(baseline, 12.5 weeks)
- Social Skills Performance Assessment (SSPA)(baseline, 12.5 weeks)
- Specific Levels of Functioning Scale (SLOF)(baseline, 12.5 weeks)
- Independent Living Skills Survey (ILSS)(baseline, 12.5 weeks)
- Defeatist Performance Attitudes Scale (DPAS)(baseline, 12.5 weeks)
- Scale for the Assessment of Negative Symptoms (SANS)(baseline, 12.5 weeks)
Study Sites (1)
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