Does Dexamethasone and Lignocaine combination relieves Propofol induced pain effectively..?

Phase 3

Completed

Conditions: Medical and Surgical,

Registration Number: CTRI/2022/06/043601

Lead Sponsor: Pochinapeddi Seetharama Prasad

Brief Summary: Propofol is used intravenously for theinduction and maintenance of anaesthesia.

However, pain in the injectionsite of the arm is one of the main disadvantages of propofol.

The incidence of *propofolinjection site pain*has been reported to vary from 80% to90% when veins on

the dorsum of the hand is usedfor injection.

â€¢In different studies the authorsconcluded that lignocaine pre-treatment with a rubber tourniquet on the

forearm was effective to decreasepain on injection**.**

However, the failure rate wasabout 15-40%. despite this lignocaine or dexamethasone did not

completely controlpropofol-induced pain despite various methods to reduce propofol injectionpain, the

most effective methods not identified;thus, combination therapy suggested

Propofol releases kininogen fromthe vein wall, which triggers a local kinin cascade, The action of the

products of the kinin cascade onthe nociceptor may be enhanced by prostaglandins.

Dexamethasone inhibits prostaglandinsynthesis and also inhibits bradykinin synthesis, a product of the

plasma kallikrein-kinin cascadeas a potent anti-inflammatory agent

In addition, dexamethasone added tolignocaine for regional IV anaesthesia has been reported to improve

analgesia

Thus, as further research isrequired the present study was conducted to evaluate the efficacy of

**Dexamethasone,Lignocaine** or **combination**isassociated with additional analgesic efficacy compared

with either treatment alone inIndian population

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: All

Target Recruitment: 104

Inclusion Criteria

Age group between 18 & 75 years ASA grade 1,2 & 3 Elective & Emergency surgeries under G.A.

Exclusion Criteria

Patients not willing to be in the study group, Pregnant patients Known allergy to study drugs Patients with neurological disorders Received analgesic medication < 24 hours before surgery Infection at the site of injection thrombophlebitis psychiatric disorders renal, hepatic, or cardiac problems.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To evaluate the analgesic effect of dexamethasone,lignocaine alone or in combination in reducing the incidence of propofol injection pain.	it is evaluated after 1 minute of injecting the study drug , and during the beginning of injection of propofol

Secondary Outcome Measures

Name	Time	Method
To evaluate the severity of propofol injection site pain with Dexamethasone, Lignocaine alone or in combination	severity of propofol injection pain will be assessed at the end of the study approximate duration for total study 3 to 4 months

Trial Locations

Locations (1): Chettinad Hospital and Research Institute
🇮🇳
Kancheepuram, TAMIL NADU, India
Chettinad Hospital and Research Institute
🇮🇳Kancheepuram, TAMIL NADU, India
Pochinapeddi Seetharama Prasad
Principal investigator
08978211211
ram20mbbs@gmail.com