Live Birth Rate in Patients With Unexplained Recurrent Pregnancy Loss

Active, not recruiting

• Conditions: Preimplantation Genetic Screening; Recurrent Pregnancy Loss
• Interventions: Procedure: Preimplantation Genetic Screening(exposure)

• Registration Number: NCT04621773
• Lead Sponsor: Peking University Third Hospital

Brief Summary

STUDY AIM: to study the pregnancy outcomes and offspring development of patient with Unexplained Recurrent Pregnancy Loss Treated by PGS and spontaneous pregnancy, and to compare the health economic indicators and patient satisfaction of the two modes of pregnancy, so as to better guide the clinical treatment.

Detailed Description

400 patients with two times or more unexplained pregnancy loss, who wants to be pregnant via preimplantation genetic screening procedure or spontaneous pregnancy are intended to be enrolled. They are going to divided into two groups: PGS(preimplantation genetic screening) group and SP(spontaneous pregnancy) group. The pregnancy outcomes and offspring development of those patients will be followed up by our investigators.

Study Timeline

• Study Start: 2020-09-01
• Status Verified: 2020-11
• Study First Submitted: 2020-11-05
• Study First Submitted QC: 2020-11-05
• Last Update Submitted: 2020-11-05
• Study First Posted: 2020-11-09
• Last Update Posted: 2020-11-09
• Primary Completion: 2023-09-01
• Study Completion: 2025-09-01

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: Female
• Target Recruitment: 400

Inclusion Criteria

• patients with two times or more unexplained pregnancy loss(less than 24 weeks of gestational age, biochemical pregnancy excluded), who wants to be pregnant via preimplantation genetic screening procedure or spontaneous pregnancy.

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Exclusion Criteria

• anatomic abnormality of the reproductive system; endocrine metabolic disease; autoimmune related disease; chromosomal abnormalities; hydrosalpinx; cervical insufficiency.

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
PGS(Preimplantation Genetic Screening)	Preimplantation Genetic Screening(exposure)	patients with two times or more unexplained pregnancy loss, who wants to be pregnant via preimplantation genetic screening procedure

Primary Outcome Measures

Name	Time	Method
Live birth rate	2 years of following up	the rate of the birth of a living fetus

Trial Locations

Locations (1)

Center of Reproductive Medicine, Peking University Third Hospital; 🇨🇳 Beijing, Haidian, China