Effectiveness of Cognitive Behavior Therapy for Persons With Depression

Not Applicable

Completed

• Conditions: Depression
• Interventions: Other: cognitive behavior therapy

• Registration Number: NCT05724680
• Lead Sponsor: Rajshahi University

Brief Summary

This was a randomized controlled clinical trial (RCT) carried out in three different hospitals in Dhaka city, Bangladesh.

Detailed Description

This was a randomized controlled trial, conducted to determine the effectiveness of CBT for depression delivered by trained therapists with an adapted Bengali CBT (BaCBT) manual, as compared to a control group. The main objective of the current study was to examine the efficacy of CBT for persons with major depression in Bangladesh.

Study Timeline

• Study Start: 2018-08-10
• Primary Completion: 2019-05-10
• Study Completion: 2019-05-30
• Study First Submitted: 2023-01-23
• Status Verified: 2023-02
• Study First Submitted QC: 2023-02-10
• Last Update Submitted: 2023-02-10
• Study First Posted: 2023-02-13
• Last Update Posted: 2023-02-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 148

Inclusion Criteria

• Diagnosed with Major Depression
• Must be able to take therapeutic session

Exclusion Criteria

• active suicidal ideation
• a co-morbid serious health condition
• with psychotic features
• currently on medication for depression
• with an intellectual disability

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Wait list control group	cognitive behavior therapy	* waitlist control group * offer CBT after completing data collection.
Treatment group	cognitive behavior therapy	cognitive behavior therapy * one session per week * six to eight session

Primary Outcome Measures

Name	Time	Method
Change in Depression Scale	change from baseline to day 42, a separate outcome from day 42 to day 72	Depression Scale to measure depression. The total scale scores range from 30 to 150. Higher scores mean worse outcomes.

Secondary Outcome Measures

Name	Time	Method
Change in Anxiety Scale	change from baseline to day 42, a separate outcome from day 42 to day 72	Anxiety Scale, the possible range of scores from 0 to 144 and Higher scores mean worse outcomes.
Change in General Health Questionnaire-28	change from baseline to day 42, a separate outcome from day 42 to day 72	General Health Questionnaire-28, range of scores from 0 to 84, and Higher scores mean worse outcomes.
Change in Beck Scale for Suicidal Ideation	change from baseline to day 42, a separate outcome from day 42 to day 72	Beck Scale for Suicidal Ideation, range of scores from 0 to 42, and Higher scores mean worse outcomes.

Trial Locations

Locations (1)

Dr. Jesan ara; 🇧🇩 Rājshāhi, Rajshahi, Bangladesh