Efficacy of Plain Cholecalciferol Tablets vs. Ergocalciferol in Raising Serum Vitamin D Level in Thai Female Healthcare Workers
- Conditions
- Vitamin D deficiency in health care providersVitamin D insufficiency in health care providersVitamin D deficiencyVitamin D insufficiencyHypovitaminosis D
- Registration Number
- TCTR20221127002
- Lead Sponsor
- Police Osteoporosis and Getriatric Excellence Center
- Brief Summary
Daily cholecalciferol supplementation resulted in a larger increase in serum 25(OH)D level during the first six months comparing to weekly ergocalciferol. While vitamin D3 could increase serum (OH)D level in all participants, vitamin D2 could not do so in participants without vitamin D deficiency.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Female
- Target Recruitment
- 67
The inclusion criteria were adult female aged 25 to 65 years without history of osteoporosis or fragility fractures as defined by fractures from a simple fall.
The exclusion criteria were prescription of vitamin D or calcium supplement within the past year, history of anti-osteoporotic medication use, including hormonal replacement therapy, and prescription of anticonvulsants or steroids. Underlying medical conditions that could affect bone metabolism; for example, hypocalcemia, hypercalcemia, uncontrolled hyperthyroidism, hypogonadism, primary hyperparathyroidism, growth hormone deficiency, acromegaly, hemochromatosis and chronic liver diseases, hematological disorders, renal disorders including chronic kidney disease, and autoimmune disorders, were also excluded.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method serum 25-hydroxy vitamin D level (25(OH)D)) Baseline, 6 months, 12 months Chemiluminescent microparticle immunoassay (CMIA) on Architect I2000SR analyzer (Abbott Laboratories Limited, USA)
- Secondary Outcome Measures
Name Time Method Compliance Baseline, 6 months, 12 months Medical possesstion ratio