Cholecalciferol in elderly with osteoarthritis of the hip.
- Conditions
- vitamin D, deficiency, total hip, cholecalciferol, osteoarthritis
- Registration Number
- NL-OMON27613
- Lead Sponsor
- RdGG hospital
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 80
Inclusion Criteria
1. Informed consent signed by patient;
2. Male and female patients aged 70 years and older;
Exclusion Criteria
1. Unwillingness to cooperate with the study procedures;
2. History of an active malignancy;
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To determine the effect of 150,000 vs 300,000 IU cholecalciferol on serum 25-OHD on day 3, 5, 14 and after 6 weeks and 3 months in patients undergoing major orthopaedic surgery or receiving conservative treatment.
- Secondary Outcome Measures
Name Time Method 1. To determine the effect of 150,000 vs 300,000 IU cholecalciferol on serum calcium and PTH on day 3, 5, 14 and after 6 weeks and 3 months;<br /><br>2. To determine the effect of surgery on the absorption of cholecalciferol;<br /><br>3. To determine the effect of surgery on serum calcium and PTH;<br /><br>4. To determine whether there is a wash-out period of the effect of cholecalciferol during 3 months of follow up, i.e. what is the time serum 25-OHD is remains above 50nmol/liter after a single oral dose of cholecalciferol;<br /><br>5. To determine changes in general well being measured by SF-12;<br /><br>6. To determine whether there is relapse of patients from sufficient to insufficient or deficient.<br>