Effect of cholecalciferol on the systolic blood pressure in hypertensive, vitamine D insufficient patients.

Completed

• Conditions: high blood pressure; hypertension; 10047635

• Registration Number: NL-OMON39286
• Lead Sponsor: Bronovo Ziekenhuis

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2014-12-18
• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 109

Inclusion Criteria

- the patient has signed an informed consent
- the patient is an adult male or female (age 18 yr or above)
- the patient is diagnosed with a systolic hypertension (> 140 mmHg), measured in Bronovo Hospital between t=-12 months and t=0 months
- the patient is vitamin D insufficient, defined as having a 25-hydroxycholecalciferol concentration between 20-50 nmol/l measured in Bronovo Hospital between t=-12 months and t=0 months

Exclusion Criteria

- using prescribed cholecalciferol supplement (>= 400 IE/day) after t = -2 months
- MDRD below normal for age/gender
- for albumin corrected serum calcium > 2,60 mmol/L
- existing malignancy which is treated.
- disease of Besnier-Boeck (sarcoidosis)
- pregnancy

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>systolic blood pressure</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Plasma renin activity<br /><br>Aldosteron<br /><br>25-hydroxycholecalciferol<br /><br>Alkaline phosphatase<br /><br>Parathyroid hormone<br /><br>the need of adjusting the antihypertensive therapy<br /><br>anti-inflammatoire activity of vitamin D</p><br>