Human short chain fatty acid metabolism and microbiota
Recruiting
- Conditions
- ObesitasObesity10003018
- Registration Number
- NL-OMON37878
- Lead Sponsor
- Medisch Universitair Ziekenhuis Maastricht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 20
Inclusion Criteria
Patients undergoing pylorus preserving pancreactico duodenectomy
18 < Age < 75 years old
Exclusion Criteria
Ileo- or colostomy
Parenchymal and/or inflammatory liver disease
Steroid hormone medication
n-acetyl cystein medication
Lactation, pregnancy and planning of pregnancy
Inflammatory bowel disease
Coagulation disorders
Excessive drinking (>20 alcoholic consumptions per week) and/or smoking
Inborn errors of metabolism (liver enzyme deficiencies)
Use of antibiotics during and 3 months prior to the study
Pre-and probiotic use during and 3 months prior to the study
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The primary study parameter is the plasma concentration of the SCFAs acetic<br /><br>acid, propionic acid and butyric acid in human measured using High Performance<br /><br>Liquid Chromatograpy (HPLC-MS).</p><br>
- Secondary Outcome Measures
Name Time Method <p>Other study parameters:<br /><br><br /><br>Duodenal biopsy: SCFA- receptors GPR41 and GPR43, hormones that influence<br /><br>substrate and energy metabolism (GLP-1, PYY), metabolites (FIAF).<br /><br><br /><br>Liver biopsy: markers for substrate, energy and/or cholesterol metabolism;<br /><br>glucose 6-phosphate, SREBP-1 expression,</p><br>