Energetic Response to Feeding and Exercise in SCI

Not Applicable

Completed

• Conditions: Spinal Cord Injuries

• Registration Number: NCT03545867
• Lead Sponsor: University of Miami

Brief Summary

This study investigates the effect of various forms of upper extremity exercise on postprandial glycemia and lipemia in persons with spinal cord injury (SCI). Participants are measured at rest and fed a standardized meal following seated rest (CON), moderate intensity continuous arm cycling (MICT), high intensity interval arm cycling (HIIT), and circuit resistance exercise (CRT) matched for exercise energy expenditure.

Detailed Description

Not available

Study Timeline

• Study Start: 2018-02-28
• Study First Submitted: 2018-05-22
• Study First Submitted QC: 2018-05-22
• Study First Posted: 2018-06-04
• Primary Completion: 2018-09-30
• Study Completion: 2018-09-30
• Status Verified: 2018-10
• Last Update Submitted: 2020-06-17
• Last Update Posted: 2020-06-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

• Adult (>/=18 years of age)
• Neurologically stable chronic (>/= 1year) spinal cord injury (SCI)
• American Spinal Injury Association Impairment Scale (AIS) grade A, B, or C
• SCI at level </= the first thoracic vertebrae (T1)

Exclusion Criteria

• Being of ≤ 18 years of age.
• Contraindication to exercise (ACSM Guideline, 10th edition)
• Lower extremity fracture or dislocation within 6 months of participation,
• History head injury or seizures.
• Inability to consent.
• Restrictions in upper extremity range of motion that would prevent an individual from achieving an unhindered arm cycling motion or moving throughout a range needed to perform resistance maneuvers.
• A pressure ulcer at ischial/gluteus, trochanteric, sacral, or heel sites within the last 3 months.
• Pregnancy determined by urine testing in sexually active females.
• Imprisonment in state or federal jail or prison.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: FACTORIAL

Primary Outcome Measures

Name	Time	Method
Postprandial insulin sensitivity	2.5 hr	Measured by "ISIMatsuada" insulin sensitivity index. This index is calculated based on the ratio of blood glucose and insulin.

Secondary Outcome Measures

Name	Time	Method
Lipemia	2.5 hr	Measured by blood concentrations of triglycerides.
Carbohydrate use	2.5 hr	Whole-body rates of carbohydrate oxidation, as determined by open-circuit indirect calorimetry.
Fasted insulin sensitivity	Baseline	Measured by "HOMA-2" model. This model is calculated based on the ratio of blood glucose and insulin.
Fat use	2.5 hr	Whole-body rates of fat oxidation, as determined by open-circuit indirect calorimetry.

Trial Locations

Locations (1)

Lois Pope Life Center; 🇺🇸 Miami, Florida, United States