Energetic Response to Feeding and Exercise in SCI

Not Applicable

Completed

• Conditions: Spinal Cord Injuries
• Interventions: Behavioral: Seated control (CON); Behavioral: Circuit resistance training (CRT); Behavioral: Moderate intensity continuous (MICT); Behavioral: High intensity interval training (HIIT); Other: Liquid Meal

• Registration Number: NCT03545867
• Lead Sponsor: University of Miami

Brief Summary

This study investigates the effect of various forms of upper extremity exercise on postprandial glycemia and lipemia in persons with spinal cord injury (SCI). Participants are measured at rest and fed a standardized meal following seated rest (CON), moderate intensity continuous arm cycling (MICT), high intensity interval arm cycling (HIIT), and circuit resistance exercise (CRT) matched for exercise energy expenditure.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2018-02-28
• Study First Submitted: 2018-05-22
• Study First Submitted QC: 2018-05-22
• Study First Posted: 2018-06-04
• Primary Completion: 2018-09-30
• Study Completion: 2018-09-30
• Status Verified: 2018-10
• Last Update Submitted: 2020-06-17
• Last Update Posted: 2020-06-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

• Adult (>/=18 years of age)
• Neurologically stable chronic (>/= 1year) spinal cord injury (SCI)
• American Spinal Injury Association Impairment Scale (AIS) grade A, B, or C
• SCI at level </= the first thoracic vertebrae (T1)

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Exclusion Criteria

• Being of ≤ 18 years of age.
• Contraindication to exercise (ACSM Guideline, 10th edition)
• Lower extremity fracture or dislocation within 6 months of participation,
• History head injury or seizures.
• Inability to consent.
• Restrictions in upper extremity range of motion that would prevent an individual from achieving an unhindered arm cycling motion or moving throughout a range needed to perform resistance maneuvers.
• A pressure ulcer at ischial/gluteus, trochanteric, sacral, or heel sites within the last 3 months.
• Pregnancy determined by urine testing in sexually active females.
• Imprisonment in state or federal jail or prison.

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: FACTORIAL

Arm && Interventions

Group	Intervention	Description
Seated control (CON)	Seated control (CON)	Participants remain seated in their habitual wheel chair for \~45 min (duration of exercise performed in other arms). Following the intervention they are fed.
Circuit resistance training (CRT)	Circuit resistance training (CRT)	Participants complete upper extremity resistance maneuvers (lifts) interspersed with low-load/high-speed arm cycling for a combined 30 repetitions of 6 lifts and \~20 min of arm cycling. During this time energy expenditure is measured via open-circuit indirect calorimetry. Following the intervention they are fed.
Moderate intensity continuous (MICT)	Liquid Meal	Participants complete continous arm cycling at a steady-state power output (intensity) matched to the energy expenditure (kcal/min) and duration of exercise (min) response during CRT. Following the intervention they are fed.
Circuit resistance training (CRT)	Liquid Meal	Participants complete upper extremity resistance maneuvers (lifts) interspersed with low-load/high-speed arm cycling for a combined 30 repetitions of 6 lifts and \~20 min of arm cycling. During this time energy expenditure is measured via open-circuit indirect calorimetry. Following the intervention they are fed.
Moderate intensity continuous (MICT)	Moderate intensity continuous (MICT)	Participants complete continous arm cycling at a steady-state power output (intensity) matched to the energy expenditure (kcal/min) and duration of exercise (min) response during CRT. Following the intervention they are fed.
High intensity interval training (HIIT)	Liquid Meal	Participants complete interval arm cycling at power output that varies between 2 min "active" and two min "recovery" periods. This interval exercise is matched to the total energy expenditure (accumulated kcals) response during CRT. Following the intervention they are fed.
High intensity interval training (HIIT)	High intensity interval training (HIIT)	Participants complete interval arm cycling at power output that varies between 2 min "active" and two min "recovery" periods. This interval exercise is matched to the total energy expenditure (accumulated kcals) response during CRT. Following the intervention they are fed.
Seated control (CON)	Liquid Meal	Participants remain seated in their habitual wheel chair for \~45 min (duration of exercise performed in other arms). Following the intervention they are fed.

Primary Outcome Measures

Name	Time	Method
Postprandial insulin sensitivity	2.5 hr	Measured by "ISIMatsuada" insulin sensitivity index. This index is calculated based on the ratio of blood glucose and insulin.

Secondary Outcome Measures

Name	Time	Method
Lipemia	2.5 hr	Measured by blood concentrations of triglycerides.
Carbohydrate use	2.5 hr	Whole-body rates of carbohydrate oxidation, as determined by open-circuit indirect calorimetry.
Fasted insulin sensitivity	Baseline	Measured by "HOMA-2" model. This model is calculated based on the ratio of blood glucose and insulin.
Fat use	2.5 hr	Whole-body rates of fat oxidation, as determined by open-circuit indirect calorimetry.

Trial Locations

Locations (1)

Lois Pope Life Center; 🇺🇸 Miami, Florida, United States