Exercise-stimulated Muscle Glucose Uptake in Upper Body Obesity

Not Applicable

Recruiting

• Conditions: Upper Body Obesity
• Interventions: Other: Exercise

• Registration Number: NCT04532814
• Lead Sponsor: Mayo Clinic

Brief Summary

The purpose of this study is to provide the first integrated examination of the interaction between muscle insulin action and exercise-stimulated muscle glucose uptake in obesity from the whole body to the cellular/molecular level.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2020-08-27
• Study First Submitted QC: 2020-08-27
• Study First Posted: 2020-08-31
• Study Start: 2020-11-06
• Status Verified: 2024-03
• Last Update Submitted: 2024-03-21
• Last Update Posted: 2024-03-22
• Primary Completion: 2025-07
• Study Completion: 2025-07

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 48

Inclusion Criteria

For the exercise studies of leg glucose uptake - "insulin sensitive" group:

• Sedentary, normal weight, premenopausal women.
• Sedentary, age-matched normal weight men.
• Weight stable for two (2) months prior to study.
• Willing to provide written, informed consent.
• For the exercise studies of leg glucose uptake - "insulin resistant" group:

For the exercise studies of leg glucose uptake - "insulin resistant" group:

• Upper body obese (UBO) premenopausal women.
• Age-matched upper body obese (UBO) men.
• Weight stable for two (2) months prior to study.
• Willing to provide written, informed consent.

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Exclusion Criteria

• Age < 18 or > 55 years (premenopausal women and age-matched men).
• Use of glucose-lowering agents.
• For female subjects: positive pregnancy test at the time of enrollment or study
• History of prior upper abdominal surgery such as adjustable gastric banding, pyloroplasty and vagotomy.
• Active systemic illness or malignancy.
• Symptomatic macrovascular or microvascular disease.

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Lean	Exercise	Control
Obese	Exercise	-

Primary Outcome Measures

Name	Time	Method
Skeletal muscle glucose uptake	1 hour	Is exercise induced skeletal muscle glucose uptake different in obese compared to lean adults

Trial Locations

Locations (1)

Mayo Clinic in Rochester; 🇺🇸 Rochester, Minnesota, United States