A Magnetic Resonance Spectroscopy Study of Change in Brain Bioenergetics in Bipolar Disorder in Response to Photic Stimulation
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 试验地点
- 2
- 主要终点
- Change in brain levels of phosphocreatine (PCr), beta-nucleoside triphosphate (B-NTP), and intracellular pH (pHi).
研究概览
简要总结
This study aims to gather additional information to support the theory that bipolar disorder is due to cellular (mitochondrial) dysfunction. To test this theory adults with bipolar disorder who are not currently symptomatic will receive a one-time brain scan (magnetic resonance spectroscopy [MRS] scan) with light stimulation. To test whether any MRS findings are specific to bipolar disorder, healthy controls and adults with schizophrenia will also be included in this study.
详细描述
This study will include males and females between the ages of 18 and 55 years. Participants will include adults with stable bipolar disorder or schizophrenia as well as healthy controls. The study involves a one-time visit that includes a clinical evaluation, laboratory tests, and a magnetic resonance scan that will last approximately 90 minutes. The procedures can also be separated into two study visits, if necessary.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Male of female
- •18-55 years
- •Bipolar, currently euthymic OR schizophrenia, stable, OR healthy control with no history of psychiatric illness
- •On stable medication with no changes in the two weeks prior to enrollment
排除标准
- •History of substance abuse or dependence within 3 months of enrollment
- •Positive urine drug screen
- •Significant medical or neurological illness
- •Pregnancy
- •Any contraindication to magnetic resonance scanning, including claustrophobia
结局指标
主要结局
Change in brain levels of phosphocreatine (PCr), beta-nucleoside triphosphate (B-NTP), and intracellular pH (pHi).
时间窗: 42 minutes
次要结局
未报告次要终点
研究者
Brian P. Brennan, MD
Associate Director of Translational Neuroscience Research
Mclean Hospital