Validation of Non- Invasive Regional Transcranial Oxygen Saturation (rSO2) by Comparison With Invasive Brain Tissue Oxygenation (PbtO 2) Measurement in Patients With Severe Traumatic Brain Injury
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- correlation between rSO2 and PbtO2
研究概览
简要总结
The purpose of this study is to investigate the relationship among regional transcranial oxygen saturation (rSO2), brain tissue oxygen pressure (PbtO2) and cerebral perfusion pressure (CPP) in patients with severe traumatic brain injury (TBI).
详细描述
Experience with rsO2 assessed by near infrared spectroscopy (NIRS) in patients with severe TBI is lacking. Reports about the usefulness of rSO2 are contradictory as regards its technical reliability and clinical value. Continuous time-domain analysis comparing rSO2, PbtO2 and CPP has never been carried out and the correlation among these variables remains largely unknown. A significant association between rSO2 and these clinically important variables would suggest that cerebral oximetry provides relevant data signifying that rSO2 might be a useful tool assessing cerebral oxygenation in selected patients with TBI.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Crossover
- 时间视角
- Cross Sectional
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Severe Traumatic Brain Injury (Glasgow Coma Scale < 9)
- •Having an intraparenchymal cerebral ICP/PbtO2 catheter previously inserted.
- •Expected length of ICU stay > 1 days
排除标准
- •Patient's relatives refusal to patient's inclusion in the study
- •Patients necessitating ongoing resuscitation
- •End-stage in which death is imminent
- •Deficient signal of rSO2 impeding its proper valuation
结局指标
主要结局
correlation between rSO2 and PbtO2
时间窗: four months
次要结局
- correlation between rSO2 and CPP(four months)