Invasive and Non-Invasive Assessment of Cerebral Oxygenation in Patients With Severe Traumatic Brain Injury (TBI)
- Conditions
- Brain Injuries
- Registration Number
- NCT00703495
- Lead Sponsor
- Hospitales Universitarios Virgen del Rocío
- Brief Summary
The purpose of this study is to investigate the relationship among regional transcranial oxygen saturation (rSO2), brain tissue oxygen pressure (PbtO2) and cerebral perfusion pressure (CPP) in patients with severe traumatic brain injury (TBI).
- Detailed Description
Experience with rsO2 assessed by near infrared spectroscopy (NIRS) in patients with severe TBI is lacking. Reports about the usefulness of rSO2 are contradictory as regards its technical reliability and clinical value. Continuous time-domain analysis comparing rSO2, PbtO2 and CPP has never been carried out and the correlation among these variables remains largely unknown. A significant association between rSO2 and these clinically important variables would suggest that cerebral oximetry provides relevant data signifying that rSO2 might be a useful tool assessing cerebral oxygenation in selected patients with TBI.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 20
- Severe Traumatic Brain Injury (Glasgow Coma Scale < 9)
- Having an intraparenchymal cerebral ICP/PbtO2 catheter previously inserted.
- Expected length of ICU stay > 1 days
- Patient's relatives refusal to patient's inclusion in the study
- Patients necessitating ongoing resuscitation
- End-stage in which death is imminent
- Deficient signal of rSO2 impeding its proper valuation
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method correlation between rSO2 and PbtO2 four months
- Secondary Outcome Measures
Name Time Method correlation between rSO2 and CPP four months
Trial Locations
- Locations (1)
Hospital Universitario "Virgen del Rocío"
🇪🇸Seville, Spain