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Clinical Trials/NCT07634328
NCT07634328Active, not recruitingNot Applicable

Impact of a High-Protein Diet on Clinical Outcomes in Mechanically Ventilated Patients With Severe Pneumonia

Fayoum University1 site in 1 country60 target enrollmentStarted: October 9, 2025Last updated:
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Conditions

Trial Snapshot

Phase
Not Applicable
Status
Active, not recruiting
Enrollment
60
Locations
1
Study OverviewStudy DesignEligibility CriteriaInvestigatorsSitesRecords & IdentifiersSimilar Trials

Study Overview

Brief Summary

prospective, comparative, observational study will be conducted at the Critical Care Department, Fayoum University Hospital, to evaluate the impact of a high-protein diet versus a standard-protein diet in mechanically ventilated patients with severe pneumonia.

Detailed Description

prospective, comparative, observational study will be conducted at the Critical Care Department, Fayoum University Hospital, aims to evaluate the effect of a high-protein diet on clinical outcomes in mechanically ventilated patients with severe pneumonia, focusing on muscle preservation and weaning ability. The specific objectives are:

  1. To assess the impact of high-protein intake on skeletal muscle mass using quadriceps ultrasound.
  2. To evaluate diaphragmatic function and thickness in relation to protein intake using ultrasound.
  3. To determine the effect of high-protein nutrition on weaning success, duration of mechanical ventilation, length of hospital stay and mortality.

Study Design

Study Type
Observational
Observational Model
Cohort
Time Perspective
Prospective

Eligibility Criteria

Ages
18 Years to — (Adult, Older Adult)
Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • •Age ≥ 18 years.
  • •Mechanically ventilated patients with severe pneumonia.
  • •Expected ICU stay ≥ 72 hours.

Exclusion Criteria

  • •Patients who died before 72 hours of ICU admission.
  • •Chronic liver failure or decompensated cirrhosis.
  • •End-stage renal disease (CKD stage 5 or dialysis dependent).
  • •Neuromuscular diseases or pre-existing severe muscle wasting.
  • •Pregnancy.
  • •Patients with pre-existing malnutrition (e.g., BMI <18.5 kg/m² ).
  • •Contraindications to enteral feeding, such as:
  • •Mechanical bowel obstruction.
  • •Severe gastrointestinal bleeding.
  • •High-output fistulas involving the gastrointestinal tract.
  • •Recent gastrointestinal surgery preventing enteral access.

Investigators

Sponsor Class
Other
Responsible Party
Principal Investigator
Principal Investigator

Mahmoud Abdelnabi Abdelhalim Ahmed

Teaching Assistant of Critical Care Medicine Department

Fayoum University

Study Sites (1)

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