TCTR20190223001招募中未知
Early versus Late Allopurinol Initiation in an Acute Gout Attack: A Randomized Controlled Trial (ELAG)
avamindradhiraj University Research Fund0 个研究点目标入组 114 人开始时间: 2019年2月23日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 招募中
- 发起方
- 入组人数
- 114
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 Years 至 100 Years（—）
- 性别
- All
入选标准
- •Patients > 18 years old presented with an acute gout attack within 72 hours after onset, and crystal-proven gout by arthrocentesis founded MSU crystals
- •and at least one of the following
- •- Frequent attack ≥ 2/year, tophi by clinical exam or imaging study, CKD stage 2 or worse (Estimated Glomerular Filtration Rate < 90 ml/min/1.73m2 ), past urolithiasis, serum uric acid > 8 mg/dL during attack or comorbidities (at least one of following; hypertension, ischemic heart disease or congestive heart failure)
排除标准
- •1. CKD stage 5 (eGFR < 15) or on Renal replacement therapy
- •2. Prior use of uric lowering agents past month
- •3. History of adverse reactin to allopurinol or colchicine
- •3. Ongoing cancer treatment
- •4. concomitant use of azathioprine or cyclosporin
- •5. taking xanthine oxidase inhibitor or uricosuric agent withih 1 month
- •6. AST, ALTand/or ALP level more than 2 times of upper normal limit
- •7. Neurologic deficit resulting in decreased pain sensatin around the involve joints
- •8. During intubation
- •9. Inability to return for examinations
- •10. presence of HLA-B*5801 genes
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