The role of fat in symptom generation in patients with functional dyspepsia

Withdrawn

• Conditions: indigestion; upper abdominal complaints; 10017943

• Registration Number: NL-OMON32048
• Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 13 May 2024

Recruitment & Eligibility

• Status: Withdrawn
• Sex: Not specified
• Target Recruitment: 30

Inclusion Criteria

18-65 years old
Recurrent bothersome postprandial fullness, early satiation and/or epigastric pain
At least 2 days per week for 3 months or more

Exclusion Criteria

Esophagitis
Barrett's esophagus
Peptic ulcer disease
Prior gastrointestinal surgery
Pregnancy
Drug- or alcohol abuse

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Differences in mRNA expression between FD patients and healthy volunteers of at<br /><br>least a factor 1.5. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Significantly different apoA-IV concentrations in plasma and/or mucosal<br /><br>biopsies of FD patients and healthy volunteers.<br /><br>Significantly different CCK concentrations in plasma and/or mucosal biopsies of<br /><br>FD patients and healthy volunteers.<br /><br>Correlation mRNA expression, apoA-IV and/or CCK concentration with sensitivity<br /><br>to gastric distension and/or gastric emptying rate.</p><br>