Providing a therapeutic method for regeneration of damaged bone tissue in the oral and maxillofacial region by mononuclear cells isolated from the patient's own fat tissue
Not Applicable
- Conditions
- Patients with maxillofacial bone defects.Hypertrophy of boneM89.3
- Registration Number
- IRCT20181205041860N1
- Lead Sponsor
- Shahid Beheshti University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 20
Inclusion Criteria
The patient has a bone defect in the maxillofacial region
Exclusion Criteria
The defect should not be socket, dehiscence, fenestration, and also sinus not involved.
systemic and metabolic diseases
active infection
compromised immune system
pregnant and or lactating women
osteoporosis and osteopetrosis
previous alveolar surgery
smoking
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method In this study, safety is the main primary outcome. Timepoint: The patient will be visited one and six days as well as 1 and 6 months after surgery. But during this time, if patients have any abnormal clinical symptoms, you will be counseled or visited by telephone or in person. Method of measurement: To evaluate the safety, different parameters such as infection, inflammation, fibrosis tissue formation, local edema, local erythema, pain, dental implant rejection, dental sensitivity, and mortality will be evaluated through clinical evaluations, blood tests, CT scans Conical scans and scatological analyzes.
- Secondary Outcome Measures
Name Time Method ew bone formation. Timepoint: after 6 months from surgery. Method of measurement: analysis of Cone Beam-CT data and histology images.