Changing the timing of levothyroxine administration in hypothyroid patients.Is it efficacious?
- Conditions
- Health Condition 1: null- patients diagnosed with hypothyroidism based on laboratory parameters and on treatment with levothyroxine
- Registration Number
- CTRI/2014/07/004788
- Lead Sponsor
- Dr Reena Sherin Parveen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 60
Known hypothyroid patients on more than 1.6mcg/kg dose of levothyroxine, unchanged for last 3 months with TSH value in the laboratory reference range in the preceding 6 months.
Patients with
•History of major gastro-intestinal disease.
•History of taking any medication known to interfere with levothyroxine absorption.( bile acid sequestrants, ferrous sulphate, sucralfate, calcium carbonate, aluminium-containing antacids, phosphate binders, raloxifene and proton-pump inhibitors)
•Chronic liver and renal disease.
•Pregnant and lactating women.
•Severe acute illness or severe trauma in the last 3 months.
•Major surgery, 3 months prior to Visit 1.
•Significant cardiovascular or cerebrovascular disease.
•Known muscular or neuromuscular disease .
•Neoplastic disease.
•Signs of mental dysfunction or other factors likely to limit ability to cooperate.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method