Potential Diagnostic Biomarkers for Aortic Dissection in the Emergency Department
- Conditions
- Aortic Dissection
- Registration Number
- NCT06065306
- Lead Sponsor
- Chinese University of Hong Kong
- Brief Summary
The goal of this observational study is to determine the utility of desmosine, D-dimer and aggrecan as early diagnostic biomarkers in aortic dissection. The main questions it aims to answer are:
* To investigate the plasma levels of selected biomarkers in ED patients with confirmed aortic dissection
* To study the diagnostic performance of plasma levels of selected biomarkers for aortic dissection
* To study the association between plasma levels of selected biomarkers and clinical outcomes
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 47
-
Age ≥ 18 years
-
Presentation to the ED with first 24 hours of symptoms suggesting AD, including chest pain, upper back pain, syncope of unknown cause, symptoms of any acute perfusion deficit
-
Confirmed AD
- the diagnosis of AD adjudicated by an independent expert panel at hospital discharge or death, whichever comes first
- The expert panel will consist of (1) a specialist in Emergency Medicine and (2) a specialist in Cardiology and (3) a specialist in Cardiothoracic Surgery.
- Age <18 years old
- Pregnancy
- Surgery or stenting performed before recruitment
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Serum levels of D-Dimer, Aggrecan and Desmosine Blood samples taken preoperatively Biomarkers :Serum levels of D-Dimer, Aggrecan and Desmosine will be compared in patients with confirmed AD versus age and sex matched healthy controls
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Prince of Wales Hospital
🇭🇰Sha Tin, NT, Hong Kong