Potential Diagnostic Biomarkers for Aortic Dissection in the Emergency Department: the Aggrecan, Desmosine, D-dimer-Emergency Department (ADD-ED) Study

Chinese University of Hong Kong1 site in 1 country47 target enrollmentJune 18, 2023

ConditionsAortic Dissection

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Aortic Dissection
Sponsor: Chinese University of Hong Kong
Enrollment: 47
Locations: 1
Primary Endpoint: Serum levels of D-Dimer, Aggrecan and Desmosine
Status: Recruiting
Last Updated: 2 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The goal of this observational study is to determine the utility of desmosine, D-dimer and aggrecan as early diagnostic biomarkers in aortic dissection. The main questions it aims to answer are:

To investigate the plasma levels of selected biomarkers in ED patients with confirmed aortic dissection
To study the diagnostic performance of plasma levels of selected biomarkers for aortic dissection
To study the association between plasma levels of selected biomarkers and clinical outcomes

Registry

clinicaltrials.gov

Start Date

June 18, 2023

End Date

December 31, 2025

Last Updated

2 years ago

Study Type

Observational

Sex

All

Investigators

Sponsor

Chinese University of Hong Kong

Responsible Party

Principal Investigator

Colin Graham

Professor

Chinese University of Hong Kong

Eligibility Criteria

Inclusion Criteria

•Age ≥ 18 years
•Presentation to the ED with first 24 hours of symptoms suggesting AD, including chest pain, upper back pain, syncope of unknown cause, symptoms of any acute perfusion deficit
•Confirmed AD
•the diagnosis of AD adjudicated by an independent expert panel at hospital discharge or death, whichever comes first
•The expert panel will consist of (1) a specialist in Emergency Medicine and (2) a specialist in Cardiology and (3) a specialist in Cardiothoracic Surgery.

Exclusion Criteria

•Age \<18 years old
•Pregnancy
•Surgery or stenting performed before recruitment

Outcomes

Primary Outcomes

Serum levels of D-Dimer, Aggrecan and Desmosine

Time Frame: Blood samples taken preoperatively

Biomarkers :Serum levels of D-Dimer, Aggrecan and Desmosine will be compared in patients with confirmed AD versus age and sex matched healthy controls