Follow up of Patients With Aortic Aneurysm by Dosage of Circulant Endothelial Progenitor Cells

Not Applicable

• Conditions: Thoracic or Abdominal Aortic Aneurysm With no Indication for Surgical Treatment
• Interventions: Biological: blood taking

• Registration Number: NCT02919709
• Lead Sponsor: Centre Hospitalier Universitaire de Besancon

Brief Summary

The study aims to investigate the existence of a reliable correlation between the progression of aortic diameters and blood levels of circulant endothelial progenitor cells CD34+ in patients with not surgical aortic aneurysms.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-11
• Study First Submitted: 2016-09-27
• Study First Submitted QC: 2016-09-27
• Study First Posted: 2016-09-29
• Status Verified: 2018-07
• Last Update Submitted: 2018-07-17
• Last Update Posted: 2018-07-18
• Primary Completion: 2018-11
• Study Completion: 2018-11

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

1. Patients aged 18 or more.
2. Patients diagnosed with a thoracic or abdominal aortic aneurysm with no indication for surgical treatment (diameters > 30 mm but < 50 mm).
3. Patients accepting to sign a specific informed consent.

Exclusion Criteria

1. Unstable coronary artery disease.
2. Congenital heart disease.
3. Any evolving infectious syndrome or viral infection (HIV, HBV or HCV).
4. Any chronic inflammatory or autoimmune disease.
5. Prior administration of G-CSF; EPO; GM-CSF.
6. Liver failure.
7. Prior oncologic disease or ongoing cancer with a life expectancy < 1 year.
8. Dementia.
9. Pregnancy.
10. Patients aged < 18.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
thoracic or abdominal aortic aneurysm	blood taking	-

Primary Outcome Measures

Name	Time	Method
progenitor cells CD34+ blood levels	24 month after diagnosis

Trial Locations

Locations (1)

CHRU de Besançon; 🇫🇷 Besançon, France