nderstanding B cell biology in auto-immune diseases.
- Conditions
- Autoimmune diseasesRheumatic diseases10003816
- Registration Number
- NL-OMON53019
- Lead Sponsor
- eids Universitair Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 1095
Inclusion criteria patients
- Age 18 years or older (no minors or incapacitated subjects will be included
in the study)
- Ability to understand the patient information form and ability to provide
written informed consent.
- a definite diagnosis of rheumatoid arthritis, systemic lupus erythematodes,
ANCA-associated vasculitis, or systemic sclerosis based on current
classification criteria or
- fulfilment of the current classification criteria for *clinically suspect
arthralgia* in the concomitant presence of ACPA in serum.
- Written informed consent
Inclusion criteria healthy subjects:
- Age 18 years or older (no minors or incapacitated subjects will be included
in the study)
- Ability to understand the patient information form and ability to provide
written informed consent.
- a self-reported absence of a definite diagnosis of rheumatoid arthritis,
systemic lupus erythematosus, ANCA-associated vasculitis, or systemic sclerosis
based on current classification criteria or of complaints compatible with the
current classification criteria for *clinically suspect arthralgia*.
Exclusion criteria patients
- Individuals who fail to meet the inclusion criteria
- Individuals for whom the treating physician considers that relevant safety
issues apply (such as, for example, severe anemia) that preclude the provision
of 50 ml of peripheral blood.
- Individuals who have donated 50 ml of blood (or more) less than two weeks
prior to the respective time-point for any reason (such as routine clinical
care, participation in another study, blood donations for the blood bank, etc.)
exclusion criteria healthy subjects:
- Individuals who fail to meet the inclusion criteria
- Individuals who have donated 50 ml of blood (or more) less than two weeks
prior to the respective time-point for any reason (such as routine clinical
care, participation in another study, blood donations for the blood bank, etc.)
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Various parameters related to the phenotype and function of auto-reactive B<br /><br>cells</p><br>
- Secondary Outcome Measures
Name Time Method <p>Not applicable</p><br>